منابع مشابه
15-deoxy-Δ12,14-prostaglandin J2 in neurodegenerative diseases and cancers
Neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) appear to have no connection with cancers. In the view of cell death, however, common ground can be found between neuronal and non-neuronal diseases [1]. AD and PD are ascribed to the cell death of neurons, which should be alive under healthy conditions. In contrast, cancers are attributed to the proliferat...
متن کاملThe Cyclopentenone Prostaglandin 15-Deoxy- -Prostaglandin J2 Attenuates the Development of Acute and Chronic Inflammation
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligandactivated transcription factors that are related to retinoid, steroid, and thyroid hormone receptors. The PPARreceptor subtype seems to play a pivotal role in the regulation of cellular proliferation and inflammation. Recent evidence also suggests that the cyclopentenone prostagl...
متن کاملThe cyclopentenone prostaglandin 15-deoxy-D-prostaglandin J2 ameliorates ischemic acute renal failure
Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, Queen Mary-University of London, Charterhouse Square, London EC1M 6BQ, UK Department of Clinical and Experimental Medicine and Pharmacology, University of Messina, Messina, Italy Department of Pathology, University of Aberdeen, Aberdeen, UK Department of Medicine and Therapeutics, University of...
متن کاملRac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog
Vascular endothelial cells (ECs) are important for maintaining vascular homeostasis. Dysfunction of ECs contributes to cardiovascular diseases, including atherosclerosis, and can impair the healing process during vascular injury. An important mediator of EC response to stress is the GTPase Rac1. Rac1 responds to extracellular signals and is involved in cytoskeletal rearrangement, reactive oxyge...
متن کامل15-Deoxy-Δ12,14 Prostaglandin J2 Reduces the Formation of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice
AIM 15-deoxy-Δ¹²,¹⁴ prostaglandin J₂ (15d-PGJ₂) is a ligand of peroxisome proliferator-activated receptor γ (PPARγ) having diverse effects such as the differentiation of adipocytes and atherosclerotic lesion formation. 15d-PGJ₂ can also regulate the expression of inflammatory mediators on immune cells independent of PPARγ. We investigated the antiatherogenic effect of 15d-PGJ₂. METHODS We fed...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2002
ISSN: 0021-9258
DOI: 10.1074/jbc.m110314200